Definition: A chokepoint reaction is a reaction that
is either the unique consumer of a given metabolite (the only reaction consuming that metabolite),
or is the unique producer of a metabolite. That metabolite must have at least one reaction
that consumes it and at least one reaction that produces it (in other words, the metabolite must
not be a dead-end). In theory, chokepoint reactions make
good drug targets because disabling that reaction disrupts the only path to or from a metabolite.
The definition of a chokepoint used here was derived from:
Genome Research 14:917 (2004) "Computational analysis of Plasmodium falciparum metabolism: Organizing genomic information to facilitate drug discovery". [Pubmed].