Pathway Summary

Biosynthesis of threonine from homoserine is accomplished in a two-step pathway involving the phosphorylated intermediate O-phospho-L-homoserine.

The final product of this pathway, threonine, serves as a structural constituent of proteins and feeds into the biosynthetic pathway for isoleucine. The enzymes carrying out both steps in this pathway are regulated at the gene level by threonine- and isoleucine-dependent attenuation, as part of attenuation control of an operon that also includes a gene coding for an enzyme in the upstream pathway of homoserine biosynthesis.

Review: Patte, J.-C., Biosynthesis of Threonine and Lysine, Chapter 32 [Neidhardt96]